A Novel Hemoglobin Variant Hb Liaobu [α107(G14)Val→Leu, HBA2: c.322G>C] Detected by Matrix-Assisted Laser Desorption Ionization-Time-of-Flight Mass Spectrometry.

doi:10.1080/03630269.2022.2036186

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Article

A Novel Hemoglobin Variant Hb Liaobu [α107(G14)Val→Leu, HBA2: c.322G>C] Detected by Matrix-Assisted Laser Desorption Ionization-Time-of-Flight Mass Spectrometry.

Hemoglobin - 1 Sept 2021

Tan Xue-Mei, Liu Yan-Hui, Shang Xuan, Ye Yu-Hua, Xu Xiang-Min

Abstract excerpt

We here describe a novel hemoglobin (Hb) variant, Hb Liaobu [α107(G14)Val→Leu, HBA2: c.322G>C], in a Chinese family. The structurally abnormal α chain variant could not be detected using capillary electrophoresis (CE) and was subsequently characterized by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS), and further confirmed by reversed phase high performance liquid...

Topics

Electrophoresis, Capillary
Hemoglobins, Abnormal
Humans
Lasers
Mass Spectrometry
Mutation
alpha-Globins

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Open in PubMed

Identifiers

PMID: 35322741
DOI: 10.1080/03630269.2022.2036186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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