Article
Detection of delta F508 mutation of the cystic fibrosis gene by matrix-assisted laser desorption/ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM - 1 Jan 1995
Ch'ang L Y, Tang K, Schell M, Ringelberg C, Matteson K J, Allman S L, Chen C H
Abstract excerpt
The most common mutation of the cystic fibrosis gene is characterized by the deletion of three nucleotides that code phenylalanine in the 508 position of the cystic fibrosis transmembrane conductance regulator. We report the first measurements by matrix-assisted laser desorption/ionization (MALDI...
Topics
- Base Sequence
- Cystic Fibrosis
- DNA
- Humans
- Lasers
- Mass Spectrometry
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction