Article
Pitfalls in newborn hemoglobinopathy screening: failure to detect beta(+)-thalassemia.
The Journal of pediatrics - 1 Aug 1995
Strickland D K, Ware R E, Kinney T R
Abstract excerpt
Although universal newborn screening can reliably identify all infants with sickle cell hemoglobinopathies, the initial screening result must not be considered the definitive diagnosis. We describe 23 infants whose screening phenotype was FS or FC but whose true phenotype included hemoglobin A, establishing a definitive diagnosis of hemoglobin S or hemoglobin C in combination with beta(+)-thalassemia. Higher than...
Topics
- Anemia, Sickle Cell
- Blood Protein Electrophoresis
- Chromatography, High Pressure Liquid
- Cohort Studies
- Female
- Hemoglobin SC Disease
- Hemoglobin, Sickle
- Hemoglobins, Abnormal
- Humans
- Infant, Newborn
- Isoelectric Focusing