Article
Immunogenetic study of couples with recurrent spontaneous abortions.
European journal of obstetrics, gynecology, and reproductive biology - 1 May 1995
Bellingard V, Hedon B, Eliaou J F, Seignalet J, Clot J, Viala J L
Abstract excerpt
OBJECTIVES: Clinical observations suggest that genetic and immunologic disparity could be a factor in fecundity. The HLA system (HLA) is polymorphic and TLX (Trophoblast Lymphocyte Cross-Reactive), which is also polymorphic, seems to be linked to it. The immunologic hypothesis follows that excessive HLA and TLX-sharing could explain the rejection of a semi-allogenic blastocyst. Study objectives are therefore...
Topics
- Abortion, Habitual
- Alleles
- Base Sequence
- Female
- HLA-A Antigens
- HLA-B Antigens
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Humans
- Male
- Molecular Sequence Data
