Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The African Swine Fever Virus Thymidine Kinase Gene Is Required for Efficient Replication in Swine Macrophages and for Virulence in Swine

1 Dec 1998

Abstract excerpt

African swine fever virus (ASFV) replicates in the cytoplasm of infected cells and contains genes encoding a number of enzymes needed for DNA synthesis, including a thymidine kinase (TK) gene. Recombinant TK gene deletion viruses were produced by using two highly pathogenic isolates of ASFV through homologous recombination with an ASFV p72 promoter-beta-glucuronidase indicator cassette (p72GUS) flanked by ASFV...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Disease Management and Epidemiology
Share to Herpesvirus Infections and Treatments
Share to Vector-Borne Animal Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9811782
DOI: 10.1128/jvi.72.12.10310-10315.1998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The African Swine Fever Virus Thymidine Kinase Gene Is Required for Efficient Replication in Swine Macrophages and for Virulence in SwinePMID 9811782Read ↗

Isolation and characterization of TK-deficient mutants of African swine fever virus.Semantic proximity Read ↗

Development of a fluorescent ASFV strain that retains the ability to cause disease in swineSemantic proximity Read ↗

The C962R ORF of African Swine Fever Strain Georgia Is Non-Essential and Not Required for Virulence in SwineSemantic proximity Read ↗

ASFV Gene A151R Is Involved in the Process of Virulence in Domestic SwineSemantic proximity Read ↗

CRISPR-Cas9, a tool to efficiently increase the development of recombinant African swine fever virusesSemantic proximity Read ↗

A Nonessential African Swine Fever Virus Gene <i>UK</i> Is a Significant Virulence Determinant in Domestic SwineSemantic proximity Read ↗

Development and In Vivo Evaluation of a MGF110-1L Deletion Mutant in African Swine Fever Strain GeorgiaSemantic proximity Read ↗

African Swine Fever Virus Multigene Family 360 and 530 Genes Are Novel Macrophage Host Range DeterminantsSemantic proximity Read ↗

CRISPR/Cas Gene Editing of a Large DNA Virus: African Swine Fever VirusSemantic proximity Read ↗

Evaluation in Swine of a Recombinant African Swine Fever Virus Lacking the MGF-360-1L GeneSemantic proximity Read ↗

Differential Effect of the Deletion of African Swine Fever Virus Virulence-Associated Genes in the Induction of Attenuation of the Highly Virulent Georgia StrainSemantic proximity Read ↗

CA-CAS-01-A: A Permissive Cell Line for Isolation and Live Attenuated Vaccine Development Against African Swine Fever VirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.