Article
Chemosensitivity to triazene compounds and O6-alkylguanine-DNA alkyltransferase levels: studies with blasts of leukaemic patients.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 1995
D'Atri S, Piccioni D, Castellano A, Tuorto V, Franchi A, Lu K, Christiansen N, Frankel S, Rustum Y M, Papa G
Abstract excerpt
BACKGROUND: A clinical pilot study performed by our group showed that dacarbazine can induce a marked reduction of blast cells in patients with acute myelogenous leukaemia (AML). Leukaemic blasts (LB) from responsive patients showed low levels of O6-alkylguanine-DNA alkyltransferase (OGAT). DESIGN: An in vitro study was performed to evaluate OGAT levels and sensitivity to temozolomide (a triazene compound that...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
- Cytarabine
- Dacarbazine
- Drug Screening Assays, Antitumor
- Female
- Humans