Strain‐specific progression of α‐amanitin—treated mouse embryos beyond the two‐cell stage

Abstract excerpt

Mouse embryos produced by the fertilization of eggs from (B6D2)F1 and CF-1 mice differ in their ability to complete the second cell cycle in the presence of alpha-amanitin. Essentially all embryos obtained from CF-1 mothers arrest at the two-cell stage when cultured from the late one-cell stage in alpha-amanitin at concentrations that prevent zygotic genome activation, while up to 15% of the embryos obtained from...

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