Article
Contribution of lethal mutations to excision assays for tumour cell survival.
Acta oncologica (Stockholm, Sweden) - 1 Jan 1995
Chatterjee A, Hodgkiss R J, Rojas A
Abstract excerpt
Conventional assays of cell survival determine only the proportion of colony-forming cells, assuming that all such cells are equivalent. However, cells surviving irradiation are reported to have lower plating efficiencies than unirradiated controls, suggesting an additional component of cellular damage that is ignored in conventional survival assays, but which could contribute to therapeutic outcome. Therefore we...
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