Article
Somatostatin modulates voltage-dependent Ca2+ channels in GH3 cells via a specific G(o) splice variant.
Ciba Foundation symposium - 1 Jan 1995
Kleuss C
Abstract excerpt
In rat pituitary GH3 cells Ca2+ current through L-type channels is reduced by somatostatin. This modulation of channel activity by somatostatin receptors is mediated by a guanine nucleotide-binding regulatory protein (G protein). It is sensitive to pertussis toxin, indicating the involvement of a G(o)- or Gi-type G protein in this pathway. The identity of this G protein was determined by suppressing the...
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