Somatostatin modulates voltage-dependent Ca2+ channels in GH3 cells via a specific G(o) splice variant.

doi:10.1002/9780470514733.ch11

Back to search

Article

Somatostatin modulates voltage-dependent Ca2+ channels in GH3 cells via a specific G(o) splice variant.

Ciba Foundation symposium - 1 Jan 1995

Kleuss C

Abstract excerpt

In rat pituitary GH3 cells Ca2+ current through L-type channels is reduced by somatostatin. This modulation of channel activity by somatostatin receptors is mediated by a guanine nucleotide-binding regulatory protein (G protein). It is sensitive to pertussis toxin, indicating the involvement of a...

Topics

Animals
Calcium Channels
Cells, Cultured
GTP-Binding Proteins
Mutation
Pituitary Gland
Rats
Signal Transduction
Somatostatin

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.