Article
Efficacy of Acylfulvene Illudin analogues against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents: retention of activity against various mdr phenotypes and unusual cytotoxicity against ERCC2 and ERCC3 DNA helicase-deficient cells.
Cancer research - 1 Nov 1995
Kelner M J, McMorris T C, Estes L, Starr R J, Rutherford M, Montoya M, Samson K M, Taetle R
Abstract excerpt
Four second-generation Illudin analogues were synthesized and tested for antitumor activity using a metastatic lung carcinoma xenograft model resistant to conventional antitumor agents. One analogue, the parent illudofulvene-derivative called Acylfulvene, inhibited xenograft primary tumor growth...
Topics
- Adenocarcinoma
- Animals
- Antibiotics, Antineoplastic
- DNA Helicases
- DNA Repair
- DNA-Binding Proteins
- Disease Models, Animal
- Drosophila Proteins
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor