Article
Subclass approach for mutational spectrum analysis.
Proceedings. International Conference on Intelligent Systems for Molecular Biology - 1 Jan 1995
Rogozin I B, Glasko G V, Latkin E I
Abstract excerpt
Analysis and comparison of mutational spectra represents a burning question in molecular biology. We report an algorithm based upon the SEM subclass approach (SEM--stochastique, estimations, maximizations). Any real mutational spectrum is regarded as a mixture of standard binomial distributions. The separation procedure is run by rounds. Each iteration includes simulation, maximization and estimation. The...
Topics
- Algorithms
- Bacterial Proteins
- Base Sequence
- Escherichia coli Proteins
- Genes, Bacterial
- Lac Repressors
- Models, Genetic
- Models, Statistical
- Molecular Sequence Data
- Mutation
- Probability