Article
Subclass approach for mutational spectrum analysis.
Proceedings. International Conference on Intelligent Systems for Molecular Biology - 1 Jan 1995
Rogozin I B, Glasko G V, Latkin E I
Abstract excerpt
Analysis and comparison of mutational spectra represents a burning question in molecular biology. We report an algorithm based upon the SEM subclass approach (SEM--stochastique, estimations, maximizations). Any real mutational spectrum is regarded as a mixture of standard binomial distributions. The separation procedure is run by rounds. Each iteration includes simulation, maximization and estimation. The...
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