[Preimplantation diagnosis of delta F508 mutation of mucoviscidosis in transgenic mice].

Article

[Preimplantation diagnosis of delta F508 mutation of mucoviscidosis in transgenic mice].

Presse medicale (Paris, France : 1983) - 16 Sept 1995

Ji Y Z, Nicolas J C, Marechal V, Desire N, Pavirani A, Milliez J

Abstract excerpt

OBJECTIVE: The aim of our study was to master preimplantation diagnosis in transgenic mice. METHODS: Stage 4 or 8 cells preembryos were collected from C57BL6xCBAF1 mice, three days after mating with transgenic C57BL6xSJLF1 mice homozygous for the human gene delta F508 mutation of cystic fibrosis. A single blastomere was sampled by microbiopsy and the preembryos transferred in Swiss mice foster mothers. Molecular...

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