Article
[Preimplantation diagnosis of delta F508 mutation of mucoviscidosis in transgenic mice].
Presse medicale (Paris, France : 1983) - 16 Sept 1995
Ji Y Z, Nicolas J C, Marechal V, Desire N, Pavirani A, Milliez J
Abstract excerpt
OBJECTIVE: The aim of our study was to master preimplantation diagnosis in transgenic mice. METHODS: Stage 4 or 8 cells preembryos were collected from C57BL6xCBAF1 mice, three days after mating with transgenic C57BL6xSJLF1 mice homozygous for the human gene delta F508 mutation of cystic fibrosis....
Topics
- Animals
- Biopsy, Needle
- Cystic Fibrosis
- Embryonic Development
- Female
- Methods
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Molecular Biology
- Mutation
- Polymerase Chain Reaction
- Pregnancy
- Pregnancy, Animal
- Time Factors