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Article

A novel form of NF‐κB is induced by <i>Leishmania </i>infection: Involvement in macrophage gene expression

26 Mar 2008

Abstract excerpt

Leishmania spp. are obligate intracellular parasites that inhabit the phagolysosomes of macrophages. Manipulation of host cell signaling pathways and gene expression by Leishmania is critical for Leishmania's survival and resultant pathology. Here, we show that infection of macrophages with Leishmania promastigotes in vitro causes specific cleavage of the NF-kappaB p65 RelA subunit. Cleavage occurs in the...

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PMID: 18383035
DOI: 10.1002/eji.200737586

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