Article
Regulation of cell wall beta-glucan assembly: PTC1 negatively affects PBS2 action in a pathway that includes modulation of EXG1 transcription.
Molecular & general genetics : MGG - 21 Aug 1995
Jiang B, Ram A F, Sheraton J, Klis F M, Bussey H
Abstract excerpt
Analysis of genes involved in yeast cell wall beta-glucan assembly has led to the isolation of EXG1, PBS2 and PTC1. EXG1 and PBS2 were isolated as genes that, when expressed from multicopy plasmids, led to a dominant killer toxin-resistant phenotype. The PTC1 gene was cloned by functional complementation of the calcofluor white-hypersensitive mutant cwh47-1. PTC1/CWH47 is the structural gene for a type 2C...
Topics
- Cell Wall
- Cloning, Molecular
- Drug Resistance, Microbial
- Enzyme Activation
- Epistasis, Genetic
- Gene Expression Regulation, Fungal
- Genes, Dominant
- Genes, Fungal
- Glucan 1,3-beta-Glucosidase
- Glucans