Article
Alternative splicing of a specific cytoplasmic exon alters the binding characteristics of murine platelet/endothelial cell adhesion molecule-1 (PECAM-1).
The Journal of biological chemistry - 6 Oct 1995
Yan H C, Baldwin H S, Sun J, Buck C A, Albelda S M, DeLisser H M
Abstract excerpt
Platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a membrane glycoprotein expressed on endothelial cells, platelets, and leukocytes. Analysis of PECAM-1 expression in the developing mouse embryo has revealed the presence of multiple isoforms of murine PECAM-1 (muPECAM-1) that appeared to result from the alternative splicing of exons encoding cytoplasmic domain sequences (exons 10-16) (Baldwin, H....
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Antigens, Differentiation, Myelomonocytic
- Base Sequence
- Blood Platelets
- Cell Adhesion Molecules
- Cell Aggregation
- Cloning, Molecular