Article
Increased incidence of cystic fibrosis gene mutations in adults with disseminated bronchiectasis.
Human molecular genetics - 1 Apr 1995
Pignatti P F, Bombieri C, Marigo C, Benetazzo M, Luisetti M
Abstract excerpt
In order to identify a possible hereditary predisposition to the development of obstructive pulmonary disease of unknown origin, we have looked for the presence of Cystic Fibrosis Transmembrane Regulator (CFTR) gene mutations in unrelated patients with no signs of Cystic Fibrosis (CF). We screened for 70 common mutations, and also for rare mutations by denaturing gradient gel electrophoresis analysis. In this...
Topics
- Adult
- Aged
- Bronchiectasis
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA
- Female
- Humans
- Male
- Membrane Proteins
- Middle Aged
- Mutation