Article
Genetic history of cystic fibrosis mutations in Italy. I. Regional distribution.
Annals of human genetics - 1 Sept 1997
Rendine S, Calafell F, Cappello N, Gagliardini R, Caramia G, Rigillo N, Silvetti M, Zanda M, Miano A, Battistini F, Marianelli L, Taccetti G, Diana M C, Romano L, Romano C, Giunta A, Padoan R, Pianaroli A, Raia V, De Ritis G, Battistini A, Grzincich G, Japichino L, Pardo F, Piazza A
Abstract excerpt
Earlier analysis of the Italian population showed patterns of genetic differentiation that were interpreted as being the result of population settlements going back to pre-Roman times. DNA disease mutations may be a powerful tool in further testing this hypothesis since the analysis of diseased individuals can detect variants too rare to be resolved in normal individuals. We present data on the relative...
Read the complete abstract on PubMedTopics
- Cystic Fibrosis
- Factor Analysis, Statistical
- Gene Frequency
- Genetics, Population
- Humans