Article
Beta 1 integrins mediate adherent phenotype of human erythroblastic cell lines after phorbol 12-myristate 13-acetate induction.
The Biochemical journal - 15 Jul 1995
Molla A, Berthier R, Chapel A, Schweitzer A, Andrieux A
Abstract excerpt
We investigated the effects of phorbol ester (phorbol 12-myristate 13-acetate; PMA) treatment on the adhesive behaviour of three erythroleukaemia cell lines: HEL, LAMA-84 and AP217. In the three cell lines PMA induced an increase in expression of a megakaryocytic marker: alpha IIb beta 3 integrin, but did not promote activation of this receptor. Indeed, an antibody specific for the activated form of alpha IIb...
Topics
- Base Sequence
- Cell Adhesion
- Cell Differentiation
- Cell Line
- DNA Primers
- Down-Regulation
- Erythrocytes
- Fibronectins
- Humans
- Integrin beta1
- Integrins