Article
Forging the links between metabolism and carcinogenesis.
Mutation research - 1 Jul 2001
Guengerich F P
Abstract excerpt
Metabolism plays important roles in chemical carcinogenesis, both good and bad. The process of carcinogen metabolism was first recognized in the first half of the twentieth century and developed extensively in the latter half. The activation of chemicals to reactive electrophiles that become covalently bound to DNA and protein was demonstrated by Miller and Miller [Cancer 47 (1981) 2327]. Today many of the DNA...
Topics
- Aflatoxin B1
- Animals
- Biotransformation
- Carcinogens
- Cell Transformation, Neoplastic
- Cytochrome P-450 Enzyme System
- DNA
- DNA Adducts
- DNA Damage
- Genetic Predisposition to Disease
- History, 20th Century
- Humans