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Article

Residues 484-508 Contain a Major Determinant of the Inhibitory Epitope in the A2 Domain of Human Factor VIII

1 Jun 1995

Abstract excerpt

The A2 domain (residues 373-740) of human blood coagulation factor VIII (fVIII) contains a major epitope for inhibitory alloantibodies and autoantibodies. We took advantage of the differential reactivity of inhibitory antibodies with human and porcine fVIII and mapped a major determinant of the A2 epitope by using a series of active recombinant hybrid human/porcine fVIII molecules. Hybrids containing a...

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
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PMID: 7540171
DOI: 10.1074/jbc.270.24.14505

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