Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines.

Abstract excerpt

C biosynthesis at extrahepatic sites remote from plasma C may be important in the protection of tissues against inflammation and infection but may also contribute to tissue injury. This latter possibility is particularly relevant in the central nervous system (CNS), where several cell types are susceptible to damage by C. We have previously shown that human astrocyte-derived tumor cell lines synthesize and...

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