Article
TA1, a highly conserved oncofetal complementary DNA from rat hepatoma, encodes an integral membrane protein associated with liver development, carcinogenesis, and cell activation.
Cancer research - 1 Mar 1995
Sang J, Lim Y P, Panzica M, Finch P, Thompson N L
Abstract excerpt
Hepatocellular carcinoma is characterized by changes in gene expression associated with cell growth and differentiation. Cell surface antigenic changes have also been described based on differential antibody reactivity between normal and neoplastic liver. We obtained a novel tumor-associated cDNA...
Topics
- Amino Acid Sequence
- Animals
- Bacteriophage lambda
- Base Sequence
- Blotting, Northern
- Cell Transformation, Neoplastic
- Cloning, Molecular
- DNA Probes
- DNA, Neoplasm
- DNA, Viral
- Female
- Gene Amplification
- Gene Expression
- Genomic Library
- Liver
- Liver Neoplasms, Experimental
- Liver Regeneration
- Lymphocyte Activation