Article
Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in matrigel in vitro and angiogenesis in vivo.
Laboratory investigation; a journal of technical methods and pathology - 1 Oct 1994
Haralabopoulos G C, Grant D S, Kleinman H K, Lelkes P I, Papaioannou S P, Maragoudakis M E
Abstract excerpt
BACKGROUND: The formation of a basement membrane is the last step in the development of a new blood vessel. Matrigel, a laminin-rich reconstituted basement membrane matrix induces the differentiation of endothelial cells into capillary-like structures. EXPERIMENTAL DESIGN: The effect of inhibitors of basement membrane collagen synthesis, tricyclodecan-9-yl xanthate (D609) and 8,9-dihydroxy-7-methyl-benzo[b]...
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