Article
Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in matrigel in vitro and angiogenesis in vivo.
Laboratory investigation; a journal of technical methods and pathology - 1 Oct 1994
Haralabopoulos G C, Grant D S, Kleinman H K, Lelkes P I, Papaioannou S P, Maragoudakis M E
Abstract excerpt
BACKGROUND: The formation of a basement membrane is the last step in the development of a new blood vessel. Matrigel, a laminin-rich reconstituted basement membrane matrix induces the differentiation of endothelial cells into capillary-like structures. EXPERIMENTAL DESIGN: The effect of inhibitor...
Topics
- 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-
- Animals
- Antineoplastic Agents
- Basement Membrane
- Bridged-Ring Compounds
- Cell Adhesion
- Cell Division
- Cell Survival
- Cells, Cultured
- Collagen
- Dose-Response Relationship, Drug
- Drug Combinations
- Endothelium, Vascular
- Female
- Humans
- Laminin
- Mice
- Neovascularization, Pathologic