Article
Alteration in the antigenic structure of M1 protein of influenza A virus mutant resistant to a new antiviral compound mopyridone.
Acta virologica - 1 Feb 1994
Galabov A S, Khristova M L, Uzunov S, Wassilewa L, Bucher D J, Kharitonenkov I G
Abstract excerpt
Using 14 monoclonal antibodies (MoAbs) in solid-phase ELISA it was found that influenza virus A/Hong Kong/1/68 (H3N2) mutants resistant to the antiviral compound mopyridone as compared to the mopyridone-sensitive mutant manifested significant changes in the antigenic structure (sites 1A, 2 and 3)...
Topics
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Antigens, Viral
- Antiviral Agents
- Chick Embryo
- Drug Resistance, Microbial
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Influenza A virus
- Mutation
- Pyrimidinones
- Rimantadine
- Viral Matrix Proteins