Article
The molecular basis of canine pyruvate kinase deficiency.
Experimental hematology - 1 Aug 1994
Whitney K M, Goodman S A, Bailey E M, Lothrop C D
Abstract excerpt
Inherited hemolytic anemia due to pyruvate kinase (PK) deficiency is an autosomal recessive disease of the Basenji dog that closely resembles human PK deficiency. Characterization of transcriptional and translational expression of PK isozymes and sequencing of DNA from normal and mutant dogs were performed to identify the genetic defect in Basenji dogs. Measurement of erythrocytic PK activity by ion exchange...
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