Article
[Pyruvate kinase (PK) isozyme switching and genetic heterogeneity of PK deficiency].
Nihon rinsho. Japanese journal of clinical medicine - 1 May 1995
Kanno H
Abstract excerpt
Pyruvate kinase (PK) is a key glycolytic enzyme and has two structural genes; the L/R-gene encodes the L- and R-type PK, whereas the M-gene encodes the M1- and M2-type isozymes. The isozyme switches from the M2 to the R-type during erythroid differentiation, and recent results showed that the switching was achieved by activation of the R-PK promoter activity and the involvement of erythroid-specific transcription...
Topics
- Anemia, Hemolytic
- Cell Differentiation
- Erythrocytes
- Glycolysis
- Humans
- Isoenzymes
- Mutation
- Pyruvate Kinase