Article
Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.
Journal of virology - 1 Aug 1994
Roben P, Moore J P, Thali M, Sodroski J, Barbas C F, Burton D R
Abstract excerpt
Six recombinant human Fab fragments that were derived from the same human immunodeficiency virus type 1 (HIV-1)-infected individual and are directed against the CD4 binding site (CD4bs) of the gp120 envelope glycoprotein were studied. A range of neutralizing activity against the HIV-1 (HXBc2) iso...
Topics
- Animals
- Antibodies, Monoclonal
- Antibody Affinity
- Binding Sites
- CD4 Antigens
- Cell Line
- Cloning, Molecular
- Epitopes
- HIV Antibodies
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Immunoglobulin Fab Fragments