Characterization of monoclonal antibodies to apolipoprotein (a) and development of a chemiluminescent assay for phenotyping apolipoprotein (a) isomorphs.

Abstract excerpt

Apo(a) is linked to Lp(a) through non-covalent interactions and disulfide bond with apo B. Monoclonal antibodies were raised to reduced and carboxymethylated apo(a) in order to study apo(a) interaction with apo B and to develop a sensitive immunoassay for apo(a) and Lp(a). Nine antibodies were characterized for overlapping epitopes and for single or multiple binding sites on native Lp(a) or denatured apo(a). All...

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