Characterization of monoclonal antibodies to apolipoprotein (a) and development of a chemiluminescent assay for phenotyping apolipoprotein (a) isomorphs.

Abstract excerpt

Apo(a) is linked to Lp(a) through non-covalent interactions and disulfide bond with apo B. Monoclonal antibodies were raised to reduced and carboxymethylated apo(a) in order to study apo(a) interaction with apo B and to develop a sensitive immunoassay for apo(a) and Lp(a). Nine antibodies were ch...

Topics

• Animals
• Antibodies, Monoclonal
• Apolipoproteins A
• Electrophoresis, Polyacrylamide Gel
• Epitopes
• Female
• Hybridomas
• Immunoassay
• Lipoprotein(a)
• Luminescent Measurements
• Mice
• Mice, Inbred BALB C
• Phenotype