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Article

Acrolein genotoxicity in Drosophila melanogaster. III. Effects of metabolism modification.

Mutation research - 1 May 1994

Barros A R, Sierra L M, Comendador M A

Abstract excerpt

In order to investigate the role of metabolism in acrolein genotoxicity in D. melanogaster, the action of several metabolism modifiers, namely phenobarbital, an inducer of xenobiotic metabolism, phenylimidazole and iproniazid, inhibitors of oxidative activities of cytochrome P450, and diethyl maleate, a glutathione-depleting agent, have been assayed using the sex-linked recessive lethal (SLRL) test, with two...

Topics

Acrolein
Animals
Biotransformation
Cytochrome P-450 Enzyme Inhibitors
Drosophila melanogaster
Female
Glutathione
Imidazoles
Iproniazid
Male
Maleates
Mutagenicity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenobarbital

Source

Identifiers

PMID: 7513061
DOI: 10.1016/0165-1218(94)90035-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7513061-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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