Article
Different effect of thymidine kinase loss on TTP pools; comparison among human leukemia cell lines.
Mutation research - 16 Jan 1994
Wakazono Y, Kubota M, Sano H, Matsubara K, Hirota H, Kuwakado K, Adachi S
Abstract excerpt
Thymidine kinase (TK)-deficient cells were established from six human leukemia cell lines to evaluate the role of TK in maintaining intracellular TTP pools. The residual TK activities in mutant cells were less than 3% of those of wild-type strains, except for a B-lymphoid cell line, Ball-1 (8.7%). In a promyelocytic leukemia cell line (HL-60), a splenic B cell line (WI-L2) and Ball-1, a mutational loss of TK...
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