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Article

Transmission of Hepatitis A to Patients with Hemophilia by Factor VIII Concentrates Treated with Organic Solvent and Detergent To Inactivate Viruses

1 Jan 1994

Abstract excerpt

OBJECTIVE: To determine whether an outbreak of hepatitis A virus (HAV) infection that occurred in 52 patients with hemophilia in Italy was acquired through infusion of contaminated factor VIII or through environmental enteric transmission. DESIGN: A case-control study and a molecular analysis of HAV sequences from implicated lots of factor VIII and from infected patients. PATIENTS: The first 29 patients with...

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PMID: 7504424
DOI: 10.7326/0003-4819-120-1-199401010-00001

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