Article
Selective expression of major histocompatibility complex (MHC) antigens and modulation of T-cell differentiation in chickens with increased MHC-chromosome dosages.
Veterinary immunology and immunopathology - 1 Jun 1995
Hemendinger R A, Miller M M, Bloom S E
Abstract excerpt
Increased dosage of genes belonging to the immunoglobulin superfamily may be responsible for some of the less noticeable but targeted phenotypic disturbances seen in trisomy conditions of humans and animals. We used an avian aneuploidy model to study the specific effects of extra major histocompa...
Topics
- Aneuploidy
- Animals
- Antibodies, Monoclonal
- Antigens, Differentiation, T-Lymphocyte
- Cell Differentiation
- Chickens
- Chromosomes
- Flow Cytometry
- Gene Dosage
- Genes, MHC Class I
- Genes, MHC Class II
- Genotype
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Major Histocompatibility Complex
- T-Lymphocytes