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Article

Genetic and structural analysis of a virulence determinant in polyomavirus VP1.

Journal of virology - 1 Dec 1995

Bauer P H, Bronson R T, Fung S C, Freund R, Stehle T, Harrison S C, Benjamin T L

Abstract excerpt

The LID strain of polyomavirus differs from other laboratory strains in causing a rapidly lethal infection of newborn C3H/Bi mice. This virulent behavior of LID was attenuated by dilution, yet at sublethal doses LID was able to induce tumors at a high frequency, like its parent virus PTA. By constructing and assaying LID-PTA recombinant viruses and by DNA sequencing, the determinant of virulence in LID was mapped...

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Identifiers

PMID: 7494305
DOI: 10.1128/JVI.69.12.7925-7931.1995
PMCID: PMC189737

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