Article
Genetic and structural analysis of a virulence determinant in polyomavirus VP1.
Journal of virology - 1 Dec 1995
Bauer P H, Bronson R T, Fung S C, Freund R, Stehle T, Harrison S C, Benjamin T L
Abstract excerpt
The LID strain of polyomavirus differs from other laboratory strains in causing a rapidly lethal infection of newborn C3H/Bi mice. This virulent behavior of LID was attenuated by dilution, yet at sublethal doses LID was able to induce tumors at a high frequency, like its parent virus PTA. By cons...
Topics
- Animals
- Animals, Newborn
- Capsid
- Capsid Proteins
- Crystallography, X-Ray
- Genes, Viral
- Genotype
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Organ Specificity
- Polyomavirus
- Polyomavirus Infections
- Receptors, Virus
- Species Specificity
- Tumor Virus Infections
- Virulence