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Article

Synergy testing of vancomycin-resistant Enterococcus faecium against quinupristin-dalfopristin in combination with other antimicrobial agents.

Antimicrobial agents and chemotherapy - 1 Nov 1999

Matsumura S O, Louie L, Louie M, Simor A E

Abstract excerpt

Using checkerboard and time-kill assays, we evaluated the in vitro activity of quinupristin-dalfopristin (RP 59500) alone and in combination with five other antimicrobial agents against 12 clinical strains of vancomycin-resistant Enterococcus faecium (VREF). In time-kill studies, six VREF strains exhibited synergism with the combination of quinupristin-dalfopristin and doxycycline and three exhibited synergism...

Topics

Anti-Bacterial Agents
Bacterial Proteins
Carbon-Oxygen Ligases
Drug Synergism
Enterococcus faecium
Genotype
Gram-Positive Bacterial Infections
Humans
Microbial Sensitivity Tests
Time Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vancomycin

Vancomycin Resistance

Virginiamycin

Source

Open in PubMed Open full text

Identifiers

PMID: 10543762
DOI: 10.1128/AAC.43.11.2776
PMCID: PMC89558

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