Article
Anti-interferon immunoglobulins can improve the trisomy 16 mouse phenotype.
Teratology - 1 May 1995
Maroun L E
Abstract excerpt
Mouse trisomy 16 is a well-studied model for human chromosome 21 trisomy (Down's syndrome). The late stage trisomy 16 mouse fetus exhibits significant growth retardation, inappropriately opened eyes, and convex rather than concave back curvature. The interferons (alpha, beta, and gamma) have potent growth retarding activity, and sensitivity to these cytokines is controlled by genes that map to mouse chromosome 16...
Topics
- Animals
- Embryonic and Fetal Development
- Female
- Immunoglobulins
- Interferon Type I
- Interferon-gamma
- Male
- Mice
- Mice, Mutant Strains
- Phenotype
- Pregnancy
- Spine