Article
Context dependence of phenotype prediction and diversity in combinatorial mutagenesis.
Protein engineering - 1 Mar 1995
Delagrave S, Goldman E R, Youvan D C
Abstract excerpt
Two different combinatorial mutagenesis experiments on the light-harvesting II (LH2) protein of Rhodobacter capsulatus indicate that heuristic rules relating sequence directly to phenotype are dependent on which sets or groups of residues are mutated simultaneously. Previously reported combinator...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Gene Library
- Light-Harvesting Protein Complexes
- Molecular Sequence Data
- Mutagenesis, Insertional
- Phenotype
- Photosynthetic Reaction Center Complex Proteins
- Protein Engineering
- Rhodobacter capsulatus