Article
Context dependence of phenotype prediction and diversity in combinatorial mutagenesis.
Protein engineering - 1 Mar 1995
Delagrave S, Goldman E R, Youvan D C
Abstract excerpt
Two different combinatorial mutagenesis experiments on the light-harvesting II (LH2) protein of Rhodobacter capsulatus indicate that heuristic rules relating sequence directly to phenotype are dependent on which sets or groups of residues are mutated simultaneously. Previously reported combinatorial mutagenesis of this chromogenic protein (based on both phylogenetic and structural models) showed that substituting...
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