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Article

Close genetic linkage between HLA and congenital adrenal hyperplasia (21-hydroxylase deficiency).

Lancet (London, England) - 1 Jan 2000

Dupont B, Oberfield S E, Smithwick E M, Lee T D, Levine L S

Abstract excerpt

Congenital adrenal hyperplasia (C.A.H.) with 21-hydroxylase deficiency is an autosomal recessive disease. HLA genotyping of parents and children in six families in which more than 1 child had C.A.H. established that the gene responsible for 21-hydroxylase deficiency is closely linked to HLA. One patient had inherited a maternal HLA-A/B recombinant haplotype and studies in this family indicated that the abnormal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 74726
DOI: 10.1016/s0140-6736(77)90362-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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