Estimation of mutation rates from the number of rare alleles in a sample.

Abstract excerpt

To estimate the mutation rate from rare electrophoretic variants, a revised estimating equation is derived that takes into account the sampling distribution of the observed number of rare alleles in a sample drawn from the population. A check of the approximations used here suggests that the deri...

Topics

• Alleles
• Animals
• Electrophoresis
• Humans
• Macaca
• Models, Genetic
• Mutation
• Native Hawaiian or Pacific Islander
• Population