Initiation and promotion in cancer formation: the importance of studies on intercellular communication.

Article

Initiation and promotion in cancer formation: the importance of studies on intercellular communication.

The Yale journal of biology and medicine - 1 Jan 2000

Potter V R

Abstract excerpt

Three major theories of cancer--somatic mutation, virus causation, and faulty differentiation--are proposed to involve alterations in DNA structure. Each results finally in terms of failures in the normal intercellular communication that involves feedback between differentiated cells acting on less differentiated cells still capable of proliferation. The historical background of the latter idea is traced to...

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