Article
Genetic activity in Saccharomyces cerevisiae and thin-layer chromatographic comparisons of medical grades of pyrvinium pamoate and monopyrvinium salts.
Mutation research - 1 Jan 2000
Mehta R D, Hennig U G, von Borstel R C, Chatten L G
Abstract excerpt
The pamoate, chloride, and iodide salts of pyrvinium, a cyanine dye with anthelmintic properties, were studied in a diploid mitotic recombination and gene conversion assay system (strain D5 of Saccharomyces cerevisiae) and a haploid yeast reversion assay (strain XV185-14C). With the use of a thin-layer chromatographic (TLC) detection technique, samples of pyrvinium pamoate from several sources were found to...
Topics
- Chromatography, Thin Layer
- Mutagenicity Tests
- Mutation
- Pyrvinium Compounds
- Recombination, Genetic
- Saccharomyces cerevisiae
- Structure-Activity Relationship