Article
Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests.
Mutation research - 1 Jan 2000
Léonard A, de Meester C, Fabry L, de Saint-Georges L, Dumont P
Abstract excerpt
The mutagenicity of diphenylhydantoin (DPH) and its major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), has been re-evaluated by the Ames test using Salmonella typhimurium and, for DPH only, by an in vitro cytogenetic test with human lymphocytes and a turbidimetric assay of tubulin po...
Topics
- Aflatoxin B1
- Aflatoxins
- Animals
- Biotransformation
- Cell Survival
- Humans
- Lymphocytes
- Male
- Microsomes, Liver
- Mutagenicity Tests
- Mutagens
- Mutation
- Phenytoin