Insulin gene structure and function: a review of studies using recombinant DNA methodology.

doi:10.2337/diacare.7.4.386

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Article

Insulin gene structure and function: a review of studies using recombinant DNA methodology.

Diabetes care - 1 Jan 2000

Permutt M A, Chirgwin J, Rotwein P, Giddings S

Abstract excerpt

This review focuses on recent advances in molecular biology as they pertain to the insulin gene and diabetes mellitus. The structure of the human insulin gene is examined, and factors related to its normal functioning in the beta cells of the pancreas are explored. DNA polymorphisms near the insu...

Topics

Animals
Cloning, Molecular
DNA, Recombinant
Diabetes Mellitus, Type 1
Gene Expression Regulation
Genes
Genetic Code
Humans
Hybridization, Genetic
Insulin
Phenotype
Polymorphism, Genetic
Proinsulin
RNA, Messenger

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