Article
[Molecular mechanisms of stabilization and preparation of metabolic breaks in DNA strands in vivo. I. Tandem action of exonuclease V and DNA polymerase II].
Molekuliarnaia biologiia - 1 Jan 2000
Fradkin G E, Aĭzenberg O A, Naumova L A
Abstract excerpt
Investigation of the formation of metabolic imbalance breaks in the DNA of thy- cells of E. coli during thymine starvation is described. The results of experiments indicate that two enzymes--exonuclease V and 3' exonuclease activity of DNA polymerase II take part in the formation of metabolic imbalance gaps. The manifestation of activity of the enzymes has a tandem character.
Topics
- DNA Polymerase II
- DNA, Bacterial
- DNA-Directed DNA Polymerase
- Deoxyribonucleases
- Drug Stability
- Escherichia coli
- Exodeoxyribonuclease V
- Exonucleases
- Kinetics
- Mutation