Genetic and Conventional Risk Stratification Are Complementary for Primary Prevention of CAD.

Abstract excerpt

Primary prevention of coronary artery disease (CAD) needs to be initiated early in young asymptomatic individuals (20s, 30s). Current pooled cohort equation (PCE) risk stratification for CAD is based on conventional risk factors often not present until the fifth or sixth decade. Genetics accounts for 50% of risk for CAD. The number of DNA risk variants present in an individual, referred to as a polygenic risk...

Topics

• Humans
• Coronary Artery Disease
• Genetic Predisposition to Disease
• Risk Assessment
• Primary Prevention
• Genetic Risk Score