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Article

Real-time, cross-modal genotype mapping of free-moving Drosophila larvae via simultaneous mechano-electrophysiological recording.

Science advances - 18 Sept 2026

Dong Kairu, Song Hao, Zhao Qianhui, Song Zhiying, Lv Fu, Wan Siouwen, Zheng Tianyu, Fan Yunlong, Liu Wen-Che, Zhang Shaomin, Wu Yongjun, Huang Yuhui, Song Jizhou, Gong Zhefeng, Zheng Nenggan, Nan Kewang

Abstract excerpt

Drosophila larvae provide a powerful model for interrogating genes associated with human muscle and neurological disorders; however, existing genotyping and phenotyping approaches remain low-throughput and often rely on destructive, invasive, or toxic procedures. Here, we present a scalable bioelectronic platform that enables real-time, simultaneous mechano-electrophysiological recording from freely moving...

Read the complete abstract on PubMed

Topics

Animals
Larva
Genotype
Electrophysiological Phenomena
Drosophila
Drosophila melanogaster

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Locomotion

Source

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Identifiers

PMID: 42758840
DOI: 10.1126/sciadv.aef7492
PMCID: PMC13588200

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