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Article

Integrated analysis of VEGFA rs833061 (- 460T > C) promoter polymorphism and serum YKL-40 levels in bladder cancer: evidence of a genotype-phenotype association.

Molecular biology reports - 16 Sept 2026

Kaushik Rohit, Pawar Devender, Sharma Anuradha, Siwach Kiran, Rohilla Gulshan, Narwal Sonia, Khatri Nisha, Arora Ankit, Vashist Minakshi

Abstract excerpt

BACKGROUND: Angiogenesis plays a central role in bladder cancer progression. VEGFA regulates angiogenesis, whereas YKL-40 is a pro-angiogenic biomarker. The relationship between VEGFA polymorphism and circulating YKL-40 remains unclear. METHODS AND RESULTS: A hospital-based case-control study involving 120 bladder cancer patients and 120 age- and sex-matched healthy controls was conducted. VEGFA rs833061...

Read the complete abstract on PubMed

Topics

Humans
Chitinase-3-Like Protein 1
Urinary Bladder Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Vascular Endothelial Growth Factor A

Case-Control Studies

Male

Genetic Association Studies

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Middle Aged

Aged

Genotype

Neovascularization, Pathologic

Biomarkers, Tumor

Source

Identifiers

PMID: 42747566
DOI: 10.1007/s11033-026-12776-w

Genes

VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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