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Article

Plasma-Derived Extracellular Vesicle microRNAs in Multiple Sclerosis: An Exploratory Case-Control Study on Phenotypic Discrimination.

International journal of molecular sciences - 22 Aug 2026

Vrînceanu Oana, Manu Doina, Maier Smaranda, Bănescu Claudia, Carstea Ana-Claudia, Bălașa Rodica

Abstract excerpt

Distinguishing relapsing-remitting multiple sclerosis (RRMS) from secondary-progressive disease (SPMS) remains a clinical challenge, as no single laboratory test reliably identifies the transition. We explored whether plasma extracellular-vesicle (EV) microRNAs could separate the two phenotypes. Four candidate EV-miRNAs: miR-30a-5p, miR-223-5p, miR-155-5p, and miR-146a-5p, were quantified by qRT-PCR in...

Read the complete abstract on PubMed

Topics

Humans
MicroRNAs
Female
Extracellular Vesicles
Case-Control Studies
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Phenotype

Biomarkers

Middle Aged

Multiple Sclerosis

Multiple Sclerosis, Relapsing-Remitting

Source

Open in PubMed Open full text

Identifiers

PMID: 42737436
DOI: 10.3390/ijms27177530
PMCID: PMC13565455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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