Article
AAT/SERPINA1 Pi*Z variant linked to gestational length and preterm birth prevention via AAT in mice.
Nature communications - 13 Aug 2026
Koivulehto E, Pasanen A, Haapalainen A M, Tiensuu H, Rämet M, Hallman M
Abstract excerpt
About 10% of pregnancies end prematurely before 37 weeks, without effective prevention therapies. Previously, we identified rare damaging variants in SERPINA1 encoding alpha-1-antitrypsin (AAT) in families with recurrent spontaneous preterm births and detected decreased protein and transcript levels of AAT/SERPINA1 from placentas in spontaneous preterm births. Here, we investigate genetic associations between...
Read the complete abstract on PubMedTopics
- Animals
- alpha 1-Antitrypsin
- Female
- Premature Birth
- Pregnancy
- Mice
- Humans