Article
Exploring Causal Links Between 91 Circulating Inflammatory Proteins and Hashimoto's Thyroiditis: A Bidirectional Mendelian Randomization Study.
Mediators of inflammation - 1 Jan 2026
Ding Shuting, Su Weiqiang, Wu Minghao, Fu Min, Wang Meng, Ji Hongzhi, Yang Bin, Zhang Zhen, Ma Chenyu, Pan Jiani, Di Xue, Zhang Xin, Zhao Xiaohua, Sun Xiaodong, Kong Yujia
Abstract excerpt
BACKGROUND: Increasing evidence has linked inflammation to Hashimoto's thyroiditis (HT) etiology. However, the causal role of circulating inflammatory proteins in HT remains uncertain. To investigate this, we conducted a bidirectional Mendelian randomization (MR) study. METHODS: Genetic data for 91 inflammatory proteins and HT were sourced from publicly available GWAS databases. The PhenoScanner database was then...
Read the complete abstract on PubMedTopics
- Humans
- Hashimoto Disease
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
- Inflammation