Article
A systematic review and network meta-analysis of first-line EGFR-TKI-based combination strategies for EGFR-mutant non-small cell lung cancer with brain metastases.
Scientific reports - 2 Sept 2026
Ma Jiayun, Zhao Weixing, Guo Wanjing, Li Zirui, Lu Xinxin, Yang Xiujin, Jia Chenyu, Zhou Qi, Jiang Jun
Abstract excerpt
Brain metastases are common in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) and remain clinically challenging despite the improved central nervous system activity of third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs). Because direct comparisons between active first-line combination strategies are limited, this systematic review and network meta-analysis (NMA)...
Read the complete abstract on PubMedTopics
- Humans
- Carcinoma, Non-Small-Cell Lung
- Brain Neoplasms
- ErbB Receptors
- Lung Neoplasms
- Protein Kinase Inhibitors